Exhaust rattle maybe... When it's in a gear (drive, reverse, etc) you have a load on it... and it naturally vibrates, and shakes more... When it's in park, or neutral there no load on the engine, and it spins freely.
You could have someone pop it into drive, and start peeking around until you find it... but the majority of the time we get that complaint it is usually an exhaust component... cat, or muffler shields vibrating.... tail pipe tapping, or something to that effect. Good Luck!